MANGANESE SUPEROXIDE DISMUTASE AND BREAST CANCER RECURRENCE: A DANISH CLINICAL REGISTRY-BASED CASE-CONTROL STUDY, AND A META-ANALYSIS.

Manganese superoxide dismutase (MnSOD) inhibits oxidative damage and cancer therapy effectiveness.A polymorphism in its encoding gene (SOD2: Val16Ala rs4880) may confer poorer breast cancer survival, but data are inconsistent.We examined the association of SOD2 genotype and breast cancer recurrence (BCR) among patients treated with cyclophosphamide

Weather and climate extremes might propel adaptation both to a stable climate and its characteristic extremes, as well as to underlying changes, if they reveal vulnerabilities, cause damage, and make slow change more noticeable.In theory, extremes act as focusing events that overcome barriers to adaptation and accelerate policy responses.This pace-